@article { author = {Saadat, Mostafa}, title = {Distribution of ACE insertion/deletion (I/D) polymorphism in Iranian populations}, journal = {Molecular Biology Research Communications}, volume = {4}, number = {2}, pages = {63-66}, year = {2015}, publisher = {Shiraz University Press}, issn = {2322-181X}, eissn = {2345-2005}, doi = {10.22099/mbrc.2015.2960}, abstract = {Angiotensin converting enzyme (ACE; OMIM: 106180) has an important role in the conversion of angiotensin I to angiotensin II and degradation of bradykinin. Genetic polymorphism I/D (rs4646994) in the gene encoding ACE has been well defined. To get more insight into the genetic structure of Iranian populations, the distribution of the ACE I/D polymorphism among Iranians was compared with each other and with other populations. Prevalence of the D allele was 0.5886 (95% CI: 0.5725-0.6047) in Iran. There was significant difference between Iranian populations (Chi2=27.7, df=6, P2=10.15, df=5, P=0.071). The D allele showed high frequency in Iran which is similar to Caucasians.}, keywords = {ACE,Iran,Polymorphism,Population genetics}, url = {https://mbrc.shirazu.ac.ir/article_2960.html}, eprint = {https://mbrc.shirazu.ac.ir/article_2960_8b2c5c96c6ed4f3281029da8284b4901.pdf} }