TY - JOUR ID - 3919 TI - Comparative genomics of human stem cell factor (SCF) JO - Molecular Biology Research Communications JA - MBRC LA - en SN - 2322-181X AU - Dehbashi, Moein AU - Kamali, Elahe AU - Vallian, Sadeq AD - Genetics Division, Department of Biology, Faculty of Science, University of Isfahan, Isfahan, Iran Y1 - 2017 PY - 2017 VL - 6 IS - 1 SP - 1 EP - 11 KW - Stem cell factor KW - Comparative genomics KW - Chimpanzee KW - Neanderthal DO - 10.22099/mbrc.2017.3919 N2 - Stem cell factor (SCF) is a critical protein with key roles in the cell such as hematopoiesis, gametogenesis and melanogenesis. In the present study a comparative analysis on nucleotide sequences of SCF was performed in Humanoids using bioinformatics tools including NCBI-BLAST, MEGA6, and JBrowse. Our analysis of nucleotide sequences to find closely evolved organisms with high similarity by NCBI-BLAST tools and MEGA6 showed that human and Chimpanzee (Pan troglodytes) were placed into the same cluster. By using JBrowse, we found that SCF in Neanderthal had a single copy number similar to modern human and partly conserved nucleotide sequences. Together, the results approved the gene flow and genetics similarity of SCF among human and P. troglodytes. This may suggest that during evolution, SCF gene transferred partly intact either on the basis of sequence or function from the same ancestors to P. troglodytes, the ancient human like Neanderthal, and then to the modern human. UR - https://mbrc.shirazu.ac.ir/article_3919.html L1 - https://mbrc.shirazu.ac.ir/article_3919_d628b6ad0b3c1a3d52373b0606d906c6.pdf ER -