Effects of associated SCF and G-CSF on liver injury two weeks after liver damage: A model induced by thioacetamide administration

Document Type: Original article


1 Department of Biochemistry and Biophysics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran

2 Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran

3 Department of Anatomical Sciences, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran

4 Department of Pathology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran


The present study aimed at investigating the beneficial effects of co-administering granulocyte colony–stimulating factor (G-CSF) and stem cell factor (SCF) in a model of chronic liver injury induced by thioacetamide (TAA). Biochemical and histopathology- cal examinations were performed on serum and liver specimens. At the end of the treatment period, the rats were anesthetized with ether, serum was collected and sections of randomly selected fixed liver specimens from each group were embedded in paraffin and processed for light microscopy by staining individual sections with hematoxylin-eosin (HE) stain. Administration of a combination of G-CSF+SCF was carried out two weeks after the TAA treatment. Livers of rats treated with TAA alone exhibited damage, which was significantly less in the group treated with the combination of SCF and G-CSF. Albumin level was 2.35 (g/dl) in the G-CSF+SCF and 1.03 in the TAA-alone group. These differences were statistically significant (P0.05).
The albumin level was 2,35 (g/dl) in the G-CSF +SCF and versus 1.03 in the TAA-alone group. These differences in the albumin level were statistically significant (P0.05).


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