TY - JOUR ID - 3485 TI - Analysis of IL-33 gene polymorphism (rs11792633 C/T) and risk of schizophrenia JO - Molecular Biology Research Communications JA - MBRC LA - en SN - 2322-181X AU - Kordi-Tamandani, DorMohammad AU - Bahrami, Ahmad Reza AU - Sabbaghi-ghale-no, Raziye AU - Soleimani, Hanieh AU - Baranzehi, Tayebe AD - University of sistan and Baluchestan AD - university of Ferdowssi,Mashhad, Iran Y1 - 2016 PY - 2016 VL - 5 IS - 1 SP - 45 EP - 48 KW - IL-33 KW - Polymorphism KW - Schizophrenia DO - 10.22099/mbrc.2016.3485 N2 - Recently, inflammation has been found to be a significant factor in the development of Schizophrenia (SCZ). The aim of the present research was to investigate whether interleukin-33 (IL-33, OMIM: 608678) gene polymorphism (rs11792633, C/T) is associated with the development of SCZ or not.DNA was isolated from the serum of 70 patients with SCZ and 70 healthy controls. The PCR based method was used for detection of the IL-33 polymorphism. The CT (OR=0.05, 95% CI: 0.003-0.057, P<0.001) andTT(OR=0.12, 95% CI: 0.028-0.46, P<0.001) genotypes significantly decreased the risk of SCZ. Our present findings indicate that the IL-33 polymorphism associated with the risk of SCZ. UR - https://mbrc.shirazu.ac.ir/article_3485.html L1 - https://mbrc.shirazu.ac.ir/article_3485_014c2cf0db6a88aa6897cf7d4f5a2dab.pdf ER -