Evaluation of VNTR polymorphisms of dopamine transporter gene and the risk of bipolar disorder in Zahedan, southeast Iran

Document Type : Short communication

Authors

1 Health promotion research Center, Zahedan University of Medical Sciences, Zahedan, Iran

2 Department of Psychiatry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

3 Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

4 Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

Abstract

The exact role of dopamine transporter gene (DAT1) in the pathogenesis of bipolar disorder type 1 (BD) is not understood. In the present study, we aimed to evaluate the possible association between 30, 40 and 63 bp variable number tandem repeat (VNTR) polymorphisms of DAT1 gene and the risk of type 1 (BD) in a sample of Iranian population. This case-control study was performed on 152 BD patients and 153 psychiatrically healthy subjects. Genotyping of the variant was done by polymerase chain reaction method. Totally, the findings did not support an association between DAT1 VNTR polymorphisms and the risk of BD in a sample of southeast Iranian population.

Keywords

References

1. Frye MA. Clinical practice. Bipolar disorder--a focus on depression. N Engl J Med 2011;364:51-59.
2. Bannon MJ. The dopamine transporter: role in neurotoxicity and human disease. Toxicol Appl Pharmacol 2005;204:355-360.
3. Vandenbergh DJ, Persico AM, Hawkins AL, Griffin CA, Li X, Jabs EW, Uhl GR. Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR. Genomics 1992;14:1104-1106.
4. Greenwood TA, Alexander M, Keck PE, McElroy S, Sadovnick AD, Remick RA, Kelsoe JR. Evidence for linkage disequilibrium between the dopamine transporter and bipolar disorder. Am J Med Genet 2001;105:145-151.
5. Kelsoe JR, Sadovnick AD, Kristbjarnarson H, Bergesch P, Mroczkowski-Parker Z, Drennan M, Rapaport MH, Flodman P, Spence MA, Remick RA. Possible locus for bipolar disorder near the dopamine transporter on chromosome 5. Am J Med Genet 1996;67:533-540.
6. Greenwood TA, Joo EJ, Shekhtman T, Sadovnick AD, Remick RA, Keck PE, McElroy SL, Kelsoe JR. Association of dopamine transporter gene variants with childhood ADHD features in bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 2013;162B:137-145.
7. Huang CC, Lu RB, Yen CH, Yeh YW, Chou HW, Kuo SC, Chen CY, Chang CC, Chang HA, Ho PS, Liang CS, Cheng S, Shih MC, Huang SY. Dopamine transporter gene may be associated with bipolar disorder and its personality traits. Eur Arch Psychiatry Clin Neurosci 2015;265:281-290.
8. Kim W-T, Lee S-R, Roh Y-G, Kim SI, Choi YH, Mun M-H, Jeong M-S, Koh SS, Leem S-H. Characterization of VNTRs Within the Entire Region of SLC6A3 and Its Association with Hypertension. DNA and Cell Biology 2017;36:227-236.
9. Kang AM, Palmatier MA, Kidd KK. Global variation of a 40-bp VNTR in the 3'-untranslated region of the dopamine transporter gene (SLC6A3). Biol Psychiatry 1999;46:151-160.
10. Franke B, Hoogman M, Arias Vasquez A, Heister JG, Savelkoul PJ, Naber M, Scheffer H, Kiemeney LA, Kan CC, Kooij JJ, Buitelaar JK. Association of the dopamine transporter (SLC6A3/DAT1) gene 9-6 haplotype with adult ADHD. Am J Med Genet B Neuropsychiatr Genet 2008;147B:1576-1579.
11. Bocchetta A, Piccardi MP, Palmas MA, Chillotti C, Oi A, Del Zompo M. Family-based association study between bipolar disorder and DRD2, DRD4, DAT, and SERT in Sardinia. Am J Med Genet 1999;88:522-526.
12. Kirov G, Jones I, McCandless F, Craddock N, Owen MJ. Family-based association studies of bipolar disorder with candidate genes involved in dopamine neurotransmission: DBH, DAT1, COMT, DRD2, DRD3 and DRD5. Mol Psychiatry 1999;4:558-565.
13. Souery D, Lipp O, Mahieu B, Mendelbaum K, De Martelaer V, Van Broeckhoven C, Mendlewicz J. Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission: DRD2, DRD3, DAT1, and TH genes. Am J Med Genet 1996;67:551-555.
14. Cosgrove VE, Miklowitz DJ, Rhee SH, Hawkey C, Corley R, Haberstick B, Smolen A. Association between 5HTT, DAT1, and DRD4 and bipolar disorder in youth. Psychiatry Genet 2012;22:304.

Files

Share

How to cite

Statistics