Association between CX3CR1 rs3732378 polymorphism and neovascular age-related macular degeneration in a sample of Algerian population

Document Type : Original article

Authors

1 Laboratory of molecular and cellular biology, Université des Sciences et de la Technologie d’Oran Mohamed Boudiaf, USTO-MB, Oran, Algeria

2 Thematic Agency for Research in Health Sciences ATRSS, Algeria

3 Laboratory of medical genetic applied in ophthalmology, «Hammou Boutlilis» Ophthalmology Hospital, Oran, Algeria

4 BiOSSE (Biology of Organisms: Stress, Health, Environment), Le Mans University, F-72085 Le Mans, France

Abstract

Neovascular age-related macular degeneration (nAMD) is a progressive ocular disease, responsible for central visual loss and blindness in elderly population. Increase data demonstrate that genetic factors play an important role in pathogenesis process of this disease. The aim of this study is to investigate the association between rs3732378 polymorphism in CX3CR1 gene and nAMD in a sample of Algerian patients. This case-control study consisted of 72 patients with nAMD and 124 control subjects. DNA of participants was extracted using salting out method. Genotyping was carried out using the TaqMan real-time polymerase chain reaction method. Statistical analysis was performed by SPSS.21.0. The prevalence of the risk genotype AA was higher in the nAMD group than in control group (OR=5.02, 95% CI=1.44-17.4, P=0.011). In our sample of Algerian patients, the rs3732378 polymorphism is associated with nAMD. This result may support the role of CX3CR1 gene in the pathogenesis of nAMD.  

Keywords

References

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