A review on diabetes and oral cancer: Molecular links and implications

Document Type : Invited review article

Authors

Clinical Genetics Lab, Centre Cellular and Molecular Research (The Blue Lab), Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences [SIMATS], Saveetha University, Chennai, Tamil Nadu, India

Abstract

Diabetes mellitus has been linked to an increased risk of oral cancer, with hyperglycemia and chronic inflammation contributing to malignant transformation. Accumulating evidence has highlighted the role of specific genes and biomarkers associated with the process. While hyperglycemia accelerates cancer progression, Metformin, an anti-diabetic medication, is found to reduce the recurrence. Future research should focus on understanding molecular mechanisms, developing early diagnostic tools, and assessing the impact of glycemic control in managing potentially oral malignant lesions in diabetic patients.

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