Insertion/deletion polymorphism of angiotensin-converting enzyme and chronic obstructive pulmonary disease: A case-control study on north Indian population

Document Type : Short communication

Authors

1 Department of Biotechnology, Panjab University, Chandigarh-160014, India

2 Department of Biotechnology, SUSCET, Tangori, Punjab-140306, India

Abstract

This research aimed to explore the ACE (insertion/deletion) gene association as key factor for chronic obstructive pulmonary disease (COPD) development in north Indian population. A total of 200 clinically diagnosed patients with COPD were selected against 200 healthy individuals. Genetic variations of ACE (insertion/deletion) were evaluated by using polymerase chain reaction techniques. Smoker showed higher risk of COPD (OR=1.67, 95% CI=1.12-2.48, P=0.012). Present results revealed the positive association between the DD genotype and the risk of COPD (OR= 2.14, 95% CI=1.22-3.78, P=0.006). Among smokers, DD genotype showed statistically significant association with increased risk of COPD (OR=3.10, 95% CI= 1.50-6.47, P=0.001).  

Keywords

References

1. Busquets X, MacFarlane NG, Heine-Suner D, Morla M, Torres-Juan L, Iglesias A, Llado J, Sauleda J, Agusti AG. Angiotensin-converting-enzyme gene polymorphisms, smoking and chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2007;2:329-334.
2. Rigat B, Hubert C, Corvol P, Soubrier F. PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxy peptidase 1). Nucleic Acids Res 1992;20:1433.
3. Ma Y, Tong X, Liu Y, Liu S, Xiong H, Fan H. ACE gene polymorphism is associated with COPD and COPD with pulmonary hypertension: a meta-analysis. Int J Chron Obstruct Pulmon Dis 2018;13:2435-2446.
4. Studdy PR, Lapworth R, Bird R. Angiotensin-converting enzyme and its clinical significance - a review. J Clin Pathol 1983;36:938-947.
5.Vasileiadis IE, Goudis CA, Giannakopoulou PT, Liu T. Angiotensin converting enzyme inhibitors and angiotensin receptor blockers: A promising medication for chronic obstructive pulmonary disease? COPD 2018;148-156
6. Paulin P, Maritano Furcada J, Ungaro CM, Bendelman G, Waisman GD, Castro HM, Giunta DH, Ferreyro BL. Effect of angiotensin 2 receptor blockers on chronic obstructive lung disease mortality: A retrospective cohort study. Pulm Pharmacol Ther 2017;44:78-82.
7. Kirtipal N, Sobti R, Thakur H, Janmeja A. Association of IL 10 gene polymorphism with chronic obstructive pulmonary disease in a north Indian population. Biochemical and Cellular Archives  2011;11:41-47.
8. Thakur H, Gupta L, Sobti RC, Janmeja AK, Seth A, Singh SK. Association of GSTM1, T1 genes with COPD and prostate cancer in north Indian population. Mol Biol Rep 2011;38: 1733-1739.
9. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press Cold Spring Harbor  N.Y. 1989; 2nd ed. pp. E.3-E.15.
10. Lindpaintner K, Pfeffer MA, Kreutz R. Stampfer MJ, Grodstein F, LaMotte F,Buring J, Hennekens CH. A prospective evaluation of an angiotensin-converting-enzyme genepolymorphism and the risk of ischemic heart disease. N Engl J  Med 1995;332:706-711.
11. Rahimi Z, Abdi H, Tanhapoor M, Rahimi Z, Vaisi-Raygani A, Nomani H. ACE I/D and MMP-7 A-181G variants and the risk of end stage renal disease. Mol Biol Res Commun 2017;6:41-44.
12. Mlak R,  Homa-Mlak  I,  Powrózek  T,  Mackiewicz  B, Michnar M,  Krawczyk P,  Dziedzic M, Rubinsztajn R, Chazan R, Milanowski J, Małecka-Massalska T. Impact of I/D polymorphism of ACE gene on risk of development and course of chronic obstructive pulmonary disease. Arch Med Sci 2016;2:279-287.
13. Kang SW, Kim SK, Chung JH,  Kim KI,  Kim J, Ban JY. Genetic polymorphism of angiotensin-converting enzyme and chronic obstructive pulmonary disease risk: An updated meta-analysis. Biomed Res Int 2016;2016:7636123.

Files

Share

How to cite

Statistics