Polymorphisms in CFI and ARMS genes and exudative age-related macular degeneration: Correspondence

Document Type : Letters to the Editor


1 Private Academic Consultant, Bangkok Thailand

2 Honorary professor, Dr DY Patil University, Pune, India


Dear Editor,
We would like to share ideas on the publication “Characterization of polymorphisms in CFI and ARMS genes and their association with exudative age-related macular degeneration in Algerian patients [1].” According to Abid et al., this work enriches the bank of data pertaining to the CFI and ARMS2 genes by disclosing for the first time the allelic and genotypic frequencies of these genes' polymorphisms that define the Algerian population [1]. Exudative age-related macular degeneration might or might not be impacted by the hereditary component. The effect of a polymorphism is investigated in this study. We both concur that exudative age-associated macular degeneration may be related to the underlying genetic component under research. However, exudative age-related macular degeneration has been linked to numerous genetic variations. Examples of gene polymorphisms include selectin and tumor necrosis factor-alpha polymorphisms [2, 3]. Future research should examine the implications of unexpected, possibly perplexing genetic variants.