Genetic polymorphisms in interleukin-13 (IL13) gene have been associated with asthma susceptibility in different ethnicities. We investigated the association of two polymorphisms in the IL13 gene [rs1800925 (c.-93+487C>T), and rs20541 (p.Gln144Arg)] with asthma susceptibility among Sudanese patients. A case-control study was conducted at Al-Shaab Teaching Hospital between April and October 2022. Involving fifty asthmatic patients and fifty controls. The genotypes were determined using an allele-specific polymerase chain reaction. For rs1800925, a significant association with asthma in multivariate analysis (aOR=3.15, 95% CI: 1.13–8.76; p=0.028). The T allele was the most frequent in cases and showed a significant association with asthma (aOR=1.99, 95% CI: 1.13–3.5; p=0.016). The rs20541 did not show any association with asthma. The rs1800925 is associated with an increased risk of asthma in Sudanese patients.
Abdalla, M., & Hamdan, H. (2025). IL13 gene polymorphisms among Sudanese patients with bronchial asthma: a case-control study. Molecular Biology Research Communications, 14(1), 27-30. doi: 10.22099/mbrc.2024.50865.2017
MLA
Menas A. Abdalla; Hamdan Z. Hamdan. "IL13 gene polymorphisms among Sudanese patients with bronchial asthma: a case-control study", Molecular Biology Research Communications, 14, 1, 2025, 27-30. doi: 10.22099/mbrc.2024.50865.2017
HARVARD
Abdalla, M., Hamdan, H. (2025). 'IL13 gene polymorphisms among Sudanese patients with bronchial asthma: a case-control study', Molecular Biology Research Communications, 14(1), pp. 27-30. doi: 10.22099/mbrc.2024.50865.2017
VANCOUVER
Abdalla, M., Hamdan, H. IL13 gene polymorphisms among Sudanese patients with bronchial asthma: a case-control study. Molecular Biology Research Communications, 2025; 14(1): 27-30. doi: 10.22099/mbrc.2024.50865.2017