Breast cancer susceptibility is associated with Cyclin D1 single nucleotide polymorphisms in Iran: A case-control study

Document Type : Short communication

Authors

1 Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran

2 Medicine School, Guilan Medical University, Rasht, Iran

Abstract

Breast cancer (BC) is the main cause of cancer-related death in women worldwide. We evaluated the association between the key CCND1 gene variant; rs9344 (G>A); and BC risk in Iran. In this case-control study, blood samples were obtained from 58 patients and 66 healthy controls. Genotyping was conducted by tetra-primer amplification refractory mutation system PCR (T-ARMS-PCR). Statistical analysis was performed by MedCalc software. Our results showed that the polymorphism rs9344 has an association with BC risk in the Iranian population. Based on the codominant and recessive models, carriers of the AA genotype are nearly 3.5 times more susceptible to BC than other individuals, and the AA genotype of CCND1 A870G may be a significant factor for breast cancer. Further studies are needed to clarify the roles of CCND1 polymorphism, rs9344, in breast cancer.

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